Abnormal expression of cortical cell cycle regulators underlying anxiety and depressive-like behavior in mice exposed to chronic stress
BackgroundThe cell cycle is a critical mechanism for proper cellular growth, development and viability.The p16INK4a and p21Waf1/Cip1 are important regulators of the cell cycle progression in response to internal and external stimuli (e.g., stress).Accumulating evidence sten jacket m indicates that the prefrontal cortex (PFC) is particularly vulnera