ABNORMAL EXPRESSION OF CORTICAL CELL CYCLE REGULATORS UNDERLYING ANXIETY AND DEPRESSIVE-LIKE BEHAVIOR IN MICE EXPOSED TO CHRONIC STRESS

Abnormal expression of cortical cell cycle regulators underlying anxiety and depressive-like behavior in mice exposed to chronic stress

BackgroundThe cell cycle is a critical mechanism for proper cellular growth, development and viability.The p16INK4a and p21Waf1/Cip1 are important regulators of the cell cycle progression in response to internal and external stimuli (e.g., stress).Accumulating evidence sten jacket m indicates that the prefrontal cortex (PFC) is particularly vulnera

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Positive end-expiratory pressure (PEEP) level to prevent expiratory flow limitation during cardiac surgery: study protocol for a randomized clinical trial (EFLcore study)

Abstract Background Lung dysfunction commonly occurs after cardiopulmonary bypass (CPB).Randomized evidence suggests that the presence of expiratory flow limitation (EFL) in major abdominal surgery is associated with postoperative pulmonary complications.Appropriate lung recruitment and a correctly set positive end-expiratory pressure (PEEP) level

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